|
Representative locomotor patterns
in an open field test.
Adcyap1
-/-
mice entered the center
region more often than wild-type
mice. Amphetamine (2 mg/kg) inhibited
such aberrant behavior.
|
|
The selective 5-HT
1A
receptor antagonist
WAY- 100635 (0.3 mg/kg) blocked the
action of amphetamine in
Adcyap1
-/-
mice(
B
). Interestingly, amphetamine
produced paradoxical calming effects
in wild-type mice that received the
5-HT
1A
agonist 8-OH-DPAT (0.05 mg/kg;
A
).
|
|
Schematic representation of possible
relationships between locomotor activity
and degree of stimulation of 5- HT
1A
systems.
|
|
