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Research at OU


Psychostimulant-induced Attenuation of Hyperactivity and Prepulse Inhibition Deficits in Adcyap1-deficient Mice

Representative locomotor patterns in an open field test.
Adcyap1-/- mice entered the center region more often than wild-type mice. Amphetamine (2 mg/kg) inhibited such aberrant behavior.

The selective 5-HT1A receptor antagonist WAY- 100635 (0.3 mg/kg) blocked the action of amphetamine in Adcyap1-/- mice(B). Interestingly, amphetamine produced paradoxical calming effects in wild-type mice that received the 5-HT1A agonist 8-OH-DPAT (0.05 mg/kg; A).

Schematic representation of possible relationships between locomotor activity and degree of stimulation of 5- HT1A systems.


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