Science

9	Dohi, T. ; Maruyama, A.; Yoshimura, M.; Morimoto, K.; Tohma, H.; Kita, Y. (Graduate School of Pharmaceutical Sciences) Versatile Hypervalent Iodine(III)-Catalyzed Oxidations with m-Chloroperbenzoic Acid as a Cooxidant Angewandte Chemie International Edition, 44, 6193-6196 (2005) A new and effective use of hypervalent iodine(III) reagents as catalysts involves the transformation of iodoarenes into hypervalent iodine(III) species with meta-chloroperbenzoic acid ( m CPBA) as the appropriate cooxidant. With observed turnover numbers greater than 70, this procedure paves the way for broader application of these useful oxidants in organic synthesis.

10	Ohga, K.; Takashima, Y.; Takahashi, H.; Kawaguchi, Y.; Yamaguchi, H.; Harada, A. (Graduate School of Science) Preparation of Supramolecular Polymers from a Cyclodextrin Dimer and Ditopic Guest Molecules : Control of Structure by Linker Flexibility Macromolecules, 38, 5897-5904 (2005)

11	Hashizume, K. ; Chaussidon, M. (Graduate School of Science) A Non-Terrestrial ¹⁶ O-rich Isotopic Composition for the Protosolar Nebula Nature, 434, 619-622 (2005)

12	Toyota, A. ; Yamaguchi, T.; Igashira-Kamiyama, A.; Kawamoto, T.; Konno, T. (Graduate School of Science) A Rock-Salt-Like Lattice Structure Consisting of Monocationic and Monoanionic Au ^I Ag ^I Cu ^II Supramolecular Cages of D-Penicillaminate Angewandte Chemie International Edition, 44, 1088-1092 (2005)

13	Kubo, T. 1; Shimizu, A. 1; Sakamoto, M. 1; Uruichi, M.; Yakushi, K.; Nakano, M. 2; Shiomi, D.; Sato, K.; Takui, T.; Morita, Y. 1; Nakasuji, K. 1 1 (Graduate School of Science) 2 (Graduate School of Engineering Science) Synthesis, Intermolecular Interaction, and Semiconductive Behavior of a Delocalized Singlet Biradical Hydrocarbon Angewandte Chemie International Edition, 44, 6564-6568 (2005)

14	Matsumori, N. ; Sawada, Y.; Murata, M.. (Graduate School of Science) Mycosamine Orientation of Amphotericin B Controlling Interaction with Ergosterol: Sterol-Dependent Activity of Conformation-Restricted Derivatives with an Amino-Carbonyl Bridge Journal of the American Chemical Society, 127, 10667-10675 (2005) Amphotericin B, a widely-prescribed antifungal drug, is known to interact with ergosterol and form ion-channels across biomembranes. We prepared several derivatives of the drug, in which flexibility of the sugar portion is restricted by intramolecular bridges. Ion-channel assays and conformational analyses of the derivatives demonstrated that orientations of the sugar moiety have a strong influence on ergosterol selectivity in the channel activity. These findings are expected to provide clues to designing new antibiotics with improved medicinal properties and less side-effects.

15	Maebashi, H.; Miyake, K. ; C. M. Varma (Graduate School of Engineering Science) Undressing of the Kondo Effect near the Antiferromagnetic Quantum Critical Point Physical Review Letters, 95, 207207/1-4 (2005) The Kondo effect is related to behaviors of magnetic impurity in metals and one of the most fundamental many-body phenomenon in the strongly correlated systems. This paper discusses the Kondo effect in the host metal near the antiferromagnetic quantum critical (AFQC) point, and shows that the spin of impurity cannot be screened by that of host metal, exhibiting the multichannel Kondo anomaly. The result offers us a microscopic basis for an unconventional AFQC phenomena attracting a great attention to date.

16	Custance, O.; Morita, S. (Graduate School of Engineering) Single Atomic Contact Adhesion and Dissipation in Dynamic Force Microscopy Physical Review Letters, 96, 106101/1-4 (2006) In this paper we unveil the origin of one of the remaining challenges in dynamic force microscopy working with true atomic resolution: the explanation of atomic contrast in the signal associated with the dissipation of energy in the cantilever oscillation. By combining dynamic force microscopy and spectroscopy experiments with first-principles calculations, we have unambiguously identified a dissipation channel which is related to the single atomic contract adhesion between the tip apex and the surface atoms. This dissipation channel is characterized by two different solutions in the short-range force upon the tip-apex approach and retraction with a notable hysteresis between them. At atomic level, this mainly manifests in the breaking and remaking of a single bond between the probed adatom and the beneath surface atom induced by a stronger adhesion with the tip-apex upon the retraction.

17	Tsuchiya, A.; Nagatomo, K. (Graduate School of Information Science and Technology) Conformal Field Theories Associated to Regular Chiral Vertex Operator Algebras I: Theories over the Projective Line Duke Mathematical Journal, 128, 393-471 (2005) Conformal field theory provides a way to determine critical exponents expected as the results of the large-scale limit of statistical models. In the paper we give a canonical construction of conformal field theories overt the projective line for a family of chiral algebras that are symmetries of theories. The models obtained here have the factorization property which enables us to calculate the dimension of the space of n points correlation functions in terms of 3 points correlation functions.

18	Nishino, K. 1,2; Honda, T. 3; Yamaguchi, A. 1,2 1 (Institute of Scientific and Industrial Research) 2 (Graduate School of Pharmaceutical Sciences) 3 (Research Institute for Microbial Diseases) Genome-Wide Analyses of Escherichia coli Gene Expression Responsive to the BaeSR Two-Component Regulatory System Journal of Bacteriology, 187, 1763-1772 (2005) Here, we report the novel mechanism of multi-drug resistance. The two-component regulatory system is a major bacterial signal transduction system. The genome-wide expression data sets revealed members of the BaeSR regulon and that the BaeSR two-component system enhances bacterial multi-drug resistance by inducing the expression of the mdtABC and acrD multi-drug exporter genes. This analysis enable postgenomic approach in drug-resistance studies and create a basis for overcoming drug resistance by clarifying the regulatory network of drug exporters.

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