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【Seminar】Progress toward the development of Plasmodium falciparum and Plasmodium vivax transmission blocking vaccines (TBV) by Nirbhay Kumar Ph.D.

2011年1月12日 (水) 10:00 から 11:30

Lecture title: Progress toward the development of Plasmodium falciparum and Plasmodium vivax transmission blocking vaccines (TBV)

Lecturer: Nirbhay Kumar, Ph.D. (William G. Vincent Endowed Professor and Chairman, Department of Tropical Medicine, Tulane University, School of Public Health & Tropical Medicine)

Article abstract

Vaccines targeting sexual development of malaria parasites in the mosquito midgut represent an essential tool to achieve the goal of gradual malaria elimination, ultimately eradication. Gametocyte and gamete proteins (P230 & P48/45: pre-fertilization antigens) and zygote / ookinete proteins (P25 & P28: post-fertilization antigens) have been pursued as target antigens, and the results in P. falciparum have further supported their importance as prime vaccine candidates. Although analogous proteins are also present in P. vivax, antibodies against P. falciparum antigens do not cross react with P. vivax antigens and thus development of P. vivax TBV also becomes an important goal to address the challenge of malaria elimination, especially for deployment in areas where the two co-exist. Pre-fertilization antigens are particularly important candidates because they are targets of natural immune responses during infection and thus could benefit from likely natural boosting of vaccine elicited immune responses. We have been evaluating DNA vaccines as well as recombinant proteins in our studies. In spite of the fact that methods like in vivo electroporation markedly enhance immunogenicity of DNA vaccines in mice, they still are in need of further improvements for evaluation in larger nonhuman primates and humans. We have recently reported on successful expression of full length Pfs48/45 protein in E. coli and highly effective functional immunogenicity in pre clinical studies in mice and baboons. Studies are now in progress to develop this antigen for phase I clinical trial in near future. We have recently also begun to develop expression strategies for Pvs48/45 and hope to evaluate immunogenicity of combined Pfs48/45 and Pvs48/45 cocktail targeting transmission of both P. falciparum and P. vivax.

 

日時: 2011年1月12日 (水) 10:00 から 11:30
主催: IFReC
場所: 融合型生命科学総合研究棟1F 谷口記念講堂
参加登録: 不要
連絡先: Dr. Cevayir Coban, Laboratory of Malaria Immunology, IFReC
ccoban@biken.osaka-u.ac.jp

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