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  Myocardial Regeneration Therapy for Heart Failure: Hepatocyte Growth Factor Enhances the Effect of Cellular Cardiomyoplasty



Over the past several years, increasing awareness of the shortcomings of heart transplantation and left ventricular assist system implantation has led cardiovascular surgeons to consider alternative means of treating end-stage heart failure. The recent development of cellular cardiomyoplasty has offered a new approach to restore impaired heart function. There are, however, several remaining problems. One problem is blood perfusion in the scar and another issue is cell-cell attachment in grafted cells.
We hypothesized that Hepatocyte growth factor (HGF) administration may have an important adjuvant effect in cell transplantation for chronic heart failure caused by ischemic injury.
We have demonstrated that HGF gene transfection combined with cellular cardiomyoplasty produced histologically and functionally apparent prevented the dilatation of the impaired myocardial wall. Combined therapy using cellular cardiomyoplasty and HGF gene transfection may become one of the armamentarium of regenerative therapy for chronic heart failure caused by myocardial infarction.

*Copyright (2002) Lippincott Williams and Wilkins


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