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  Altered Psychomotor Behaviors in Mice Lacking Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)



Pituitary adenylate cyclase-activating polypeptide (PACAP) is one of the most conserved neuropeptides in evolution, suggesting an important role in the regulation of basic physiological function. In this paper, we reported the generation of mice deficient in PACAP and demonstrated the involvement of PACAP in psychomotor behaviors. In comparison to wild-type control mice (left panel), PACAP-deficient mice (right panel) exhibit hyperactive and explosive jumping behaviors in a novel environment. In addition, examples of locomotor patterns during the last 10 min of a 60-min recording (insets) clearly show that PACAP-deficient mice displayed impaired habituation to the novel environment relative to wild-type mice. The study places the PACAPergic system in a new context, and may offer a molecular basis for the development and treatment of psychiatric diseases.


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