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Research at OU


1 Datta, S. ; Mori, Y. ; Takagi, K. ; Kawaguchi, K. ; Chen, Z. W. ; Okajima, T. ; Kuroda, S. ; Ikeda, T. ; Kano, K. ; Tanizawa, K. ; Mathews, F. S. (Institute of Scientific and Industrial Research)
Structure of a Quinohemoprotein Amine Dehydrogenase with an Uncommon Redox Cofactor and Highly Unusual Crosslinking
Proceedings of the National Academy of Sciences of the United States of America, 98, 14268-14273 (2001)

2 Hanada, K. ; Palacpac, N. M. Q.*1 ; Magistrado, P. A.*1 ;
Kurokawa, K.*2 ; Rai, G.*1 ; Sakata, D. ; Hara, T. ; Horii, T.*1 ;
Nishijima, M. ; Mitamura, T.*1
*1( Research Institute for Microbial Diseases) *2( Genome Information Research Center)
Plasmodium falciparum Phospholipase C Hydrolyzing Sphingomyelin and Lysocholinephospholipids Is a Possible Target for Malaria Chemotherapy
The Journal of Experimental Medicine, 195, 23-34 (2002)

Development of new antimalarial drug remains a challenge against the continuous emergence and spread of drug resistant Plasmodium parasites. Here we present a new target for malarial chemotherapy, the P. falciparum phospholipase C. Scyphostatin treatment inactivated this identified enzyme in concomitant with the inhibition of intraerythrocytic proliferation of parasite. Moreover, evidence inferred a specific effect on the stage progression from trophozoite to schizont, a stage when phospholipase C gene is in active transcription. This study, hence, is a promise to malarial chemotherapy.

3 Hashimoto, H.*1 ; Shintani, N.*1 ; Tanaka, K.*1 ; Mori, W.*1 ;
Hirose, M.*1 ; Matsuda, T.*1 ; Sakaue, M.*1 ; Miyazaki, J.*2 ;
Niwa, H.*2 ; Tashiro, F.*2 ; Yamamoto, K.*1 ; Koga, K.*1 ;
Tomimoto, S.*1 ; Kunugi, A.*1 ; Suetake, S.*1 ; Baba, A.*1
*1( Graduate School of Pharmaceutical Science) *2( Graduate School of Medicine)
Altered Psychomotor Behaviors in Mice Lacking Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)
Proceedings of the National Academy of Sciences of the United States of America, 98, 13355-13360 (2001)

4 Hishida, T. ; Ohno, T. ; Iwasaki, H. ; Shinagawa, H. (Research Institute for Microbial Diseases)
Saccharomyces Cerevisiae MGS1 Is Essential in Strains Deficient in the RAD6-Dependent DNA Damage Tolerance Pathway
EMBO Journal, 21, 2019-2029 (2002)

Progression of replication fork is often hindered by exogenous and endogenous DNA damage. The stalled replication fork is processed by enzymes involved in translesion synthesis or homologous recombination pathways, leading to replication restart and prevention of genome rearrangements. In this paper, we found that Mgs1 interacted with DNA replication machinery and play a role in preventing genome instability caused by replication fork arrest. This study provides important clues to understanding the complex interplay between DNA replication, repair, and recombination functions.

5 Honke, K. ; Hirahara, Y. ; Dupree, J. ; Suzuki, K. ; Popko, B. ; Fukushima, K. ; Fukushima, J. ; Nagasawa, T. ; Yoshida, N. ; Wada, Y. ; Taniguchi, N. (Graduate School of Medicine)
Paranodal Junction Formation and Spermatogenesis Require Sulfoglycolipids
Proceedings of the National Academy of Sciences of the United States of America, 99, 4227-4232 (2002)

Mammalian sulfoglycolipids are comprised of two major members, sulfatide and seminolipid. Sulfatide is abundant in the myelin sheath and seminolipid is rich in spermatozoa. Their sulfation is catalyzed by a single enzyme, cerebroside sulfotransferase (CST). To investigate the physiological role of sulfoglycolipids, Cst-null mice were generated by gene targeting. Cst-/- mice manifested neurological disorders due to disorganization at the node of Ranvier and a block in spermatogenesis, indicating that sulfoglycolipids are essential for the myelin function and spermatogenesis.

6 Horie, K.*1,2 ; Kuroiwa, A. ; Ikawa, M.*3 ; Okabe, M.*3 ; Kondoh. G.*2 ;
Matsuda, Y. ; Takeda, J.*1,2
*1( Collaborative Research Center for Advanced Science and Technology)
*2( Graduate School of Medicine) *3( Genome Information Research Center)
Efficient Chromosomal Transposition of a Tc1/mariner-like Transposon Sleeping Beauty in Mice
Proceedings of the National Academy of Sciences of the United States of America, 98, 9191-9196 (2001)

7 Hoshino, M. ; Katou, H. ; Hagihara, Y. ; Hasegawa, K. ; Naiki, H. ;
Goto, Y. (Institute for Protein Research)
Mapping the Core of the b2-Microglobulin Amyloid Fibril by H/D Exchange
Nature Structural Biology, 9, 332-336 (2002)

8 Kamachi, Y. ; Uchikawa, M. ; Tanouchi, A. ; Sekido, R. ;
Kondoh, H.
(Graduate School of Frontier Biosciences)
Pax6 and SOX2 Form a Co-DNA-Binding Partner Complex that Regulates Initiation of Lens Development.
Genes and Development, 15, 1272-1286 (2001)

9 Kamada, Y. ; Nagaretani, H. ; Tamura, S. ; Ohama, T. ;
Maruyama, T.
; Hiraoka, H. ; Yamashita, S. ; Yamada, A. ; Kiso, S. ; Inui, Y. ; Ito, N. ; Kayanoki, Y. ; Kawata, S. ; Matsuzawa, Y. (Graduate School of Medicine)
Vascular Endothelial Dysfunction Resulting from L-arginine Deficiency in a Patient with Lysinuric Protein Intolerance
The Journal of Clinical Investigation, 108, 717-724 (2001)

10  Kawane, K. ; Fukuyama, H. ; Kondoh, G. ; Takeda, J. ; Ohsawa, Y. ; Uchiyama, Y. ; Nagata, S. (Graduate School of Medicine)
Requirement of DNase II for Definitive Erythropoiesis in the Mouse Fetal Liver
Science, 292, 1546-1549 (2001)
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