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Seminar by Dr. Yi Zhang (HHMI, Univ. of North Carolina)

2011-11-29 (Tue) 3:30 p.m. - 4:30 p.m.

A lecture by Dr. Yi Zhang, world famous in the field of epigenetics

Lecturer: Yi Zhang, Ph.D.

Howard Hughes Medical Institute
Department of Biophysics & Biochemistry
Lineberger Comprehensive Cancer Center
University of North Carolina at Chapel Hill

Epigenetic modifications play important roles in diverse biological processes that range from regulation of gene expression, embryonic development, stem cell reprogramming, and human diseases such as cancers.

One of the epigenetic modifications is DNA methylation. Although enzymes responsible for DNA methylation have been well characterized, enzymes that responsible for active DNA demethylation in mammalian cells have remained elusive. Recent studies have demonstrated that a novel family of proteins Tet1-3 have the capacity to convert 5mC to 5hmC, 5fC, and 5caC raising the possibility that DNA demethylation may occur through Tet-catalyzed oxidation followed by decarboxylation.

In this talk, I will present our recent findings on the mechanism and functions of Tet-catalyzed dynamic regulation of DNA methylation.

Relevant references:

  1. Wu, S.C., and Zhang, Y. (2010). "Active DNA demethylation: Many roads to Rome." Nature Review MCB 11, 607-620.
  2. Ito, S., D’Alessioi, A.C., Taranova, O.V., Hong, K., Sowers, L.C., and Zhang, Y. (2010). "Role of Tet proteins in 5mC to 5hmC conversion, ES cell self-renewal, and inner cell mass specification." Nature 466, 1129-1133.
  3. Wu, H., D’Alessioi, A.C., Ito, S., Xia, K., Wang, Z., Cui, K., Zhao, K., Sun, Y., and Zhang, Y. (2011). "Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells." Nature 473, 389-93.
  4. Ito, S., Shen, L., Dai, Q., Wu, S.C., Collins, L.B., Swenberg, J.A., He, C., and Zhang, Y. (2011). "Tet proteins can convert 5-methylcytosine to 5-formalcytosine and 5-carboxylcytosine." Science 333, 1300-03.
  5. Inoue, A., and Zhang, Y. (2011). "Replication-dependent loss of 5-hydroxymethylcytosine in mouse preimplantation embryos." Science 334, 194.
  6. Inoue, A., Shen, Li., Dai, Q., He, C., and Zhang, Y. (2011). "Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development." Cell Research (in press).

Date: 2011-11-29 (Tue) 3:30 p.m. - 4:30 p.m.
Venue: Auditorium B, 2nd Floor, Lecture Bldg., Faculty of Medicine, Suita Campus
Registration: Not necessary.
Contact: Dr. Junji TAKEDA

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