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Seminars & Symposiums

15th Bridge Seminar -- Research Institute for Microbial Diseases

2011-11-18 (Fri) 5:00 p.m. - 6:00 p.m.

Osaka University's Research Institute for Microbial Diseases will hold the 15th Bridge Seminar on Friday, November 18.

Lecture topic: Membrane Phospholipid Asymmetry and its Loss
Lecturer: SUZUKI Jun, Assistant professor, Department of Medical Chemistry, Graduate School of Medicine, Kyoto University

Lecture outline

In eukaryotic organisms, phospholipids making up cell membranes are asymmetrical. Phosphatidylserines (PS) are located on the inside of the cell membrane and phosphatidylcholines are located on its outside. Flippase is an enzyme involved in phospholipid translocation to the inside of the membrane and ATP-dependent flippase contains PS on the inside the membrane.

However, the loss of phospholipid asymmetry is shown in a variety of situations in living organisms. For example, the activation of platelets induces PS emergence on cell surfaces and activates blood coagulation factors. PS, exposed during apotosis, functions as an "eat-me" signal to macrophages. It was assumed that calcium-dependent scramblase that scrambles phospholipids both on the inside and on the outside the cell was involved in PS exposure on cell surfaces, however, details of this have yet to be clarified.
This lecture will concentrate on the phospholipid scrambling mechanism that our recent research has clarified.


Date: 2011-11-18 (Fri) 5:00 p.m. - 6:00 p.m.
Organizer: Research Institute for Microbial Diseases, Osaka University
Sponsored: The Research Foundation for Microbial Diseases of Osaka University
Venue: Taniguchi Memorial Hall, 1st floor, Integrated Life Science Building, Osaka University
Registration: Not necessary.
Contact: Research Institute for Microbial Diseases, Osaka University
biken-bml@biken.osaka-u.ac.jp

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