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Genome Information Research Center Seminar: Quality Control of Proteins in the Endoplasmic Reticulum--from Immunity to Fertility

2009-7-30 (Thu) 4:00 p.m. -

 

Date and time: July 30, 2009, 4:00 - 5:00 p.m.

Proteins synthesized by translating mRNA should be correctly folded so as to allow the exertion of their function. Proteins helping to fold proteins are called molecular chaperones. This seminar is about chaperones found in the endoplasmic reticulum (ER). 

The control of protein folding is critical for cell survival, and for the manufacture of recombinant proteins for industry and medicine. When protein folding goes wrong, conditions like infertility, amyloidosis and diabetes can occur. The quality control of proteins is particularly important in the ER, a cellular compartment where secretory proteins are made for export. During protein synthesis, a protein must fold, acquire disulfide bonds and become glycosylated. 

In this seminar, Dr. Benham will discuss how the MHC class I and class II molecules of the immune system fold and form complexes, and how this relates to the binding of antigenic viral and bacterial peptides. He will discuss the function of the ER chaperones and oxidoreductases that direct the quality control process in the ER, and describe how these proteins have been co-opted for specialised functions in tissues like the testis.

 

Lecture title: Quality control of proteins in the endoplasmic reticulum--from immunity to fertility
Lecturer: Dr. Adam Benham, Biological and Biomedical Sciences, Durham University, England

He will stay in Japan as a visiting associate professor at the Genome Information Research Center from July 7, 2009 to the end of March 2010.


Date and time: July 30 (Thursday), 2009  4:00 - 5:00 p.m.

Sponsor: Department of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University

Venue: Conference Room #1, Genome Information Research Center, Osaka University

For more information, contact: Mr. OKABE Masaru, Genome Information Research Center, Tel: 06-6879-8374

Date: 2009-7-30 (Thu) 4:00 p.m. -

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